Latent Oncological Terrain

Clinical Contribution to primary Prevention of malignant Tumours.

"Not to autumn I will yield, not to winter ever" 

(W. B. Yeats)

(Note: for understanding the following review of the book “Il Terreno Oncologico. Semeiotica Biofisica: Contributo Clinico alla Prevenzione Primaria del Tumore” (in press), doctor needs accurate and complete knowledge of Biophysical Semeotics. However, in the interest of reader, who is not jet experienced in the new method, to facilitate him in the comprehension of paper, I provide some useful informations [in square parenthesis], in a very easy manner from the technical point of view).

Before illustrating Clinical Microangiology of malignant tumours, both liquid and solid, it is necessary to describe in details the oncological terrain or pre-oncological stage, where is constantly present the Congenital Acidosic Enzyme-Metabolic Histangiopathy (CAEMH), conditio sine qua non of the oncological terrain, and, therefore, of malignancy, elsewhere exhaustively illustrated (See: later on and Bibliography in Home-Page).

CAEMH-a, a congenital, functional, mythocondrial cytopathology, inherited almost from the mother, lasts all  life long, although variable in intensity, in relation to life-style, diet and employment of  both bioactive products and histangioprotective drugs.

On the contrary, oncological terrain, originated on the basis of  CAEMH-a, can disappears, to be caused or, finally, increased by unfavourale enviromental conditions, by improper diet, etymologically speaking, which acts in a negative manner on the CAEMH-a as well as on the biological systems controllling oncogenesis. In other words, oncological terrain, in which CAEMH-a plays a major role, can be  induced and fortunately reversed, almost completely, with the aid of correct diet, etymologically speaking, and by means of histangioprotective treatment (See later on).

Biophysical Semeiotics allows doctor to recognize and evaluate “quatitatively” the pre-oncological stage,i.e. oncological terrain,  by the aid of a large number of methods, different in simplicity, refinement, practical application and amount of information.. The usefulness of all these clinical methods, in doctor’s daily work, is pointed out by the fact that absence of oncological terrain rules out the presence of malignancy, influencing remarkebly the diagnostic iter, large scale screening, and therapeutic monitoring.

In fact, age, sex, familiarity have now , i.e. from biophysical semeiotic point of view, a very little value in oncological prevention, because exclusively clinical recognition of oncological terrain requires urgently that patient undergoes to instrumental and sophisticated semeiotics, early, in a rational manner, after ascertaining the microcirculatory activation type II, non-associated [= pathological preconditioning] even in a small part of well defined biological system, where preconditioning results pathological, besides to other numerous biophysical semeiotic signs (See: Early Diagnosis of Heart .... in Home-Page).

In each human there are about 1013 cells: not all of these cells, but almost all, can grow and replicate to present as a clinical cancer in every time, due mutations occuring during cellular reproduction. However, cancer is a rare disease at the cellular level. As a matter of facts, up to 30% of all individuals in the developed countries will present clinically with one of a wide variety  of cancer at some time of their life. Consequently,  if the number of cell at risk is taken into account, given the relatively small cases of malignancies, it is obvious that this disease only rarely escapes normal protective systems. Therefore, tumours can originate and grow exclusively when psycho-neuro-endocrine-immunological system is profoundly modified. As regards both primary prevention and clinical diagnosis of malignancy, in my opinion, essential is  answering to the following question:

“What does carachterize oncological terrain from the clinical point of view?”.

In fact, in order to achieve efficacious prevention on large scale it is unavoidable that all the modifications occurring in the biological controll system could be easily and promptly ascertained and properly evaluated with the aid of clinical method, i.e. by the use of a sthetoscope, and certainly without application of sophysticated semeiotics, that does not apply in all individuals, and, moreover, only a few doctors can utilize them.

If it is possible answering affirmatively to this question, a second one immediately follows:

“The oncological terrain which certanly can  be induced, is also in some way reversible?”

It is urgent and necessary to know if   the oncological terrain can be reversed, i.e. it can totally or greatly disappeare, with the aid of drugs or diet, etymologically speaking, which exert a favourable influence on modifications of the psicho-neuro-endocrine-immunological system.


At first, we must both face and resolve essential problems concerning oncological terrain, discussing, once more,  accurately the pathological mitochondrial condition, which represents its fundamental basis,  when it is particularly severe: CAEM-a. (See Congenital Acidosic Enzymo-Metabolic Histangiopaty in Home-Page)

CAEM-a, conditio sine qua non also of oncological terrain, represents actually a severe alteration of mitochondrial oxidative phosphorilation processes, i.e. ATP synthesis, as well as nucleophyl substitution, variable in intensity from individual to individual, from tissue to tissue and from part to part of the same tissue.

From morphological point of view, it is well-known that CAEM-a is characterized by prevalence of right cerebral hemisphere – right cerebral dominance – or more correctly said, of right Planum temporale, which is notoriously located between Heschl’s convolution (gyrus) and posterior part of Silvio’s fissure.

One can ascertain CAEM-a as elsewhere described (See Bibliography in Home-Page). However, it is advisable an easiest manner, briefly illustrated in following: in healthy individual in supine position and psycho-physically relaxed, doctor applies its left hand, at first, on right parietal-temporal region of the subject and then on the left one, when the individual to be examined presses forefinger-pulp and thumb-pulp together, obviously at first, of the left hand and, subsequently, of the right one; at the same time doctor evaluate somatosensorial evoked potentials (SEPs) [= in pratice, latency time of the cerebral-gastric aspecific reflex, as indicated in Fig. 1].

In case of CAEM-a, latency  time (lt) of the reflex is 6 sec.  when trigger-points of right hemisphere are stimulated, whereas lt results 7 sec. if left cerebral trigger-points are activated; in later situation, intensity of gastric aspecific reflex appears clearly lower: 2 cm versus 1 cm. respectively.  Of course, the degrees of reflex intensity are reversed in presence of dominance of left cerebral hemisphere.

At this point, in order to observe the interesting evolution from CAEM-a to oncological terrain, one must remember, once a time, an usefull biophysical semeiotic syndrome, really helpful to general pracitioner in everiday activity : the Rethyculo-Endothelial  System Hyperfunction Syndrome  (RESHS), that is subdivided in  “complete”, “intermediate” and “uncomplete” type.

As far as clinical significance is concerned, CAEM-a corresponds to ESR elevation and proteins electrophoresis alterations, but surely is of both more sensitive, specific and, therefore, reliable. In fact, in case of a slight attack of flu, e.g., ( or, even, in advanced malignancy)  it often turns out that both laboratory tests are in normal ranges, while RESHS “uncomplete”, carachteristic of this viral disease, is always present since the first, asyntopmatic stage, when evaluated by aid of the Restano’s maneouvre [= patient clinches fists and does not breath, i.e. boxer’s and simultaneously apnea test: sympathetic hypertonus] (See: Glossary in Home-Page): in healthy young person, psycho-physically relaxed, in supine position, digital pressure of “mean” intensity, applied on mean line of breast-bone, iliac crests and spleen projection area, provokes the gastric aspecific reflex after a latency time of 10 sec.: RESHS  physiological (Fig.1).

In case of bacterial infection, contagious diseases of infancy, viral in origin, connective tissue disorders (Rheumatoid Arthritis, Lupus Erithematosus, a.s.o.), malignant tumours, a.s.o., lt decreases to 6 sec. with a latency time of reinforcing [= augmentation of reflex intensity] of 8 ± 1 sec.: RESHS “complete”. On the contrary, in viral flu, as in commom flu, digital pressure, applied on cutaneous projection area of spleen does not brings about any gastric aspecific reflex, because white germ centres of splenic (red) pulp are not activated in these conditions: RESHS “uncomplete”. On the contrary, in Herpes Zoster as well as in common infectious diseases of infancy, caused by viral, RESHS is “complete”.

Finally, in bacterial disorders, provoked by Gram-negative, i.e. in common acute cystitis  (E.coli) or in antritis brought about by H. pylori, RESHS turns out to be “intermediate”  (Tab.1). 

Fig. 1


Reticulo-Endothelial System Hyperfunction Syndrome:  in the stomach, both fundus and body are clearly dilated, while antral-pyloric region  contracts (= gastric aspecific reflex), when digital pressure of mean intensity is applied on middle line of breast-bone, iliac crests and, only in the “complete” type, also on cutaneous projection area of the spleen (See text and Tab 1).

RESHS: types and clinical significances.

Type “complete” Trigger points: breast-bone, iliac crests, skin projection area of spleen Bacterial diseases, viral contagious diseases of infancy, rheumatisms, malignancy
Type “intermediate” Splenic trigger point provokes a g.a. riflex of lower intensity Disorders caused by Gram-negative (Cistytis by Esch. coli; antritis by HP)
Type “uncomplete” Spleen is not trigger-point Flu viruses

Tab. 1

Interestingly, RESHS allows doctor to monitoring in objective manner the course of wathever disorder in objective manner. As a matter of facts, the degree of both lt and lt of reflex reinforcing provides essential information about the course of the underlying illness.

From the practical view-point, it is of interest that exclusively during the changing of RESHES, from “uncomplete” to “complete” type, doctor has to prescribe immediatly, without delay, antibiotic drugs.

By a long, well-established experience,  I can state that doctor recognizes easily, with the aid of  Biophysical Semeiotics, individuals CAEMH-a-positive at  oncological  risk, quantifying it and, therefore, estimating the probability of tumorur.


In 85 % of malignant tumours, both solid and liquid, in initial stage and in 100 % when malignancy is already advanced, RESHS is of “complete” type, showing a characteristic latency time (lt) of only 3 sec. and latency time of reinforcing of 5,5 ± 0,5 sec.. On the contrary, in common viral diseases of infancy and in bacterial disorders, connectivitis, a.s.o., lt is 6 sec. and latency time of reinforcing is 8,5±0,5 sec.; p <0,001.

In patients, succesfully operated of malignant tumour, lt is 10 sec. (NN = 10 sec.), but after apnea test, lasting 10 sec. and boxer’ tests, employed simultaneously, i.e. Restano’s manoeuvre, lt is lower (3 sec.) and lt of reinforcing turns out to be 8 ± 1 sec. (Tab.1 and  2 ).

Interstingly, in healthy without positive familiarity for tumours, Restano’s manoeuvre brings about only a small modification of basal lt and lt of reinforcing is  9,5 ± 0,5 sec.

Finally, it is of great interest that  in both initial stage of tumours in 15 % of cases and patients at risk of cancer, basal value oscillate in normal ranges, but it becomes plainly pathological after Restano’s manoeuvre, obviously with different degree (Tab. 3)  

Restano’s manoeuvre and RESHS (in parentheses basal values)

  tl tl del rinforzo
85% P. with initial and  all with advanced tumour 3 sec. (3 sec.) 5,5±0,5 sec. (5,5±0,5 sec.)
P. successfully operated  of tumours 3 sec. (10 sec.) 8,5±0,5 sec. (>10 sec.)
Healthies without familiarity for tumours CAEMH-a-neg.       8,5 ±0,5 sec. (10 sec.) 9,5±0,5 sec. (>10 sec.)
P.CAEMH-a-positive but at oncological risk and 15% P. with initial neoplasm 3 sec. (10 sec.) 7±1 sec. (>10 sec.)

Tab. 2

Restano’s manoeuvre

type A: lt 3 sec gastric aspecific reflex I =/- 1 cm. tl II =/- 9 sec.
tipo B: tl 3 sec. gastric aspecific reflex I > 1 cm. tl II  6-8 sec.

Tab. 3

At this point doctor must remember the essential role, Restano’s manoeuvre plays in moving  from CAEMH-a syndrome to cancer growing. Restano’s manoeuvre represents, indeed, the activation of Reticulo-Endothelial-System, at the present time termed Monocyte-Macrophage System. As indicates Tab. 3, there are two type of this manoeuvre: type A and type B.

In order to observe and to evaluate “quantitatively” the manoeuvre, subject to be examined is invited not to breath for 10 sec. (apnea test), or alternatively doctor applies intense, occlusive digital pressure on a brachial artery for the same time (10 sec.), i.e. “variant” Restano’s manoeuvre, as well as to clinching fists: sympathetic hypertonus. Before the individual keep again to normally breath, doctor applies digital pressure on  middle line of breast-bone (or on iliac crests or cutaneous prjection area of the spleen) for evaluating RESHS [= lt of gastric aspecific reflex,i.e. sundus and body of the stomach appear dilated, while antral-pyloric region contracts,  and lt of reflex reinforcing] (Tab. 1).

As described-above, Restano’s manoeuvre points out RESHS activation. As a matter of facts, e.g. during infectious disorder, it appears earlier type A, then type B and finally RESHS, “complete”, “uncomplete” or “intermediate”, in relation to the nature od underlying disese.

On the other hand, when therapy ameliorates disorder and patient improves, first of all RESHS disappears, and therafter also type B of the manoeuvre is not ascertained, while appears type A , which lasts as far as patient  completely  recovers.

The presence of Restano’s manoeuvre type B, i.e. the activation of Reticulo-Endothelial System, is due to the fact that marrow products mononuclear cells, which migrate to the thymus and lymphoid tissues, as well as myelopeptides, that stimulate antibodies synthesis, in order to increase biological defense. Consequently, there is marrow  microcirculatory activation type I, associated [= “light” digital pressure on breast-bone, e.g.,  provokes three ureteral reflexes, which permit doctor to evaluate vasomotility and vasomotion of marrow microcirculation, by the intensity of reflexes fluctuation].

Following experimental evidence corroborates my above-illustrated interpretation: in healthy individual, “intense” digital pressure on trigger-points for evaluating RESHS (middle line of breast-bone, iliac crests) after about 20 sec. increases the antibodies biophysical semeiotic syndrome [= light digital pressur, applied on MALT skin projection, i.e. breast-, liver-, spleen-, urinary bladder-, appendix-, middle clavicular  line- a.s.o., cutaneous projection areas, provokes physiologically after 6 sec. gastric aspecific reflex of 2 cm. in intensity: chronic antibodies synthesis syndrome], that from the chronic type  becomes clearly of acute type, where lt appears to be 3 sec. and intensity > 2 cm.

On the contrary, in individual with oncological terrain stimulation of antibodies synthesis appears to be whether absent or not statistically significant (lt of MALT-gastric aspecific reflex: 5-6 sec.). Moreover, in healthy, digital pressure on middle line of breast-bone, after a lt of about 20 sec., increases the diameters of BALT cutaneous projection area  (­ 3 cm.), while  in oncological terrain they increase only £ 1 cm. [= auscultatory percussion of both posterior and anterior thoracic wall, allows doctor to ascertained , along middle scapular and, respectively, clavicular line, three round hypophonetic area – BALT -  of a diameter oscillating in a chaotic-deterministic manner, 6 times/min, from 0,5 cm. to 1,5 cm., with a period varying from 9 sec. to 12 sec.- mean value 10,5, a fractal number,  as do all biological systems].

Interestingly, in healthy individual digital pressure of mean intensity, applied on breast-bone provokes, after about 20 sec.,  intense increasing (³ 2 cm.) of BALT cutaneous projection areas, with augmentation of antibodies synthesis [= lt of MALT-gastric aspecific reflex lowers from 3 sec. and reflex intensity clearly increases to ³ 2 cm.], while in presence of oncological terrain the encreases is  £ 1 cm.).

To demonstrate both internal and external coherence of biophysical theory it is whortwhile that simultaneously, during Restano’s manoeuvre, all sites of antibodies synthesis (MALT) show biophysical semeiotic features of active hyperemia, more precisely speaking, the microcirculatory activation type I, associated (See earlier), of course of different intensity in relation to causal agent, indicating the acute phase of antibodies production.

Notably, the following clinical evidence corroborates this interpretation: in healthy, subcutaneous injection of desensitizing vaccine, according to Besredka,  induces first the type A, later type B and finally RESHS.

While in Restano’s manoeuvre type A is always contemporaneously present Selye’s syndrome, variable in intensity, beside type B doctor observe characteristic modifications of psycho-neuro-endocrine-immunological system, as in malignancy, liquid or solid, as well as in patients, who successfully underwent  to surgery. I have termed this pathological situation of biological systems for protecting against cancer as “oncological terrain”.

As regards the evaluation of neuro-stimulatotors, neuro-modulators, hormonal neuro-modulators, free-oxygen-radicals, and preconditioning see Bibliography in Home-Page.


Biophysical Semeiotics allows doctor to both recognize and “quantitatively” assess at the bed-side the biological terrain, on which cancer can originate and grow (Tab.4 and 5).

Increasing : G. H. I.G.F.s PRL free Radicals Hyperinsulinemia-insulinresistance
Reducing:: SST Oppioid Vit. A E Co. Q 10 Carnetine



BALT WITH CLOSED EYES                                   LT> 5 SEC.    I  < 3 CM.  D < 30 SEC.

 WITH CLOSED EYES                                              LT> 5 SEC. I  < 2 CM.  D < 30 SEC.


 SPLANCNIC DECONGESTION                             LT> 5 SEC.    I < 2 CM.  D < 30 SEC.

SST-RH    “IDEM”                                                      LT 5 SEC.    I < 2 CM.  D < 25 SEC.
GH-RH     “IDEM”                                                      LT> 5 SEC.    I < 2CM    D < 20 SEC.

AND  PERISTALTIC WAVE VELOCITY                  T  <  10  SEC.

SIMULATED SUCKING TEST                               D > 7   SEC.
CAEMH-a                                                PRESENT (100%)  G.aspecific REFL.> 2 CM.
PRECONDITIONING                                         PATHOLOGICAL


Complete, exhaustive biophysical semeiotic evaluation of psycho-neuro-endocrine-immunological system as well as of products, indicated in Tab.5,  needs obviously a years-long study and exprience  at the bed-side. Due to lack of space, I invite the reader, who like to complete this topic, to see former articles in Bibliography, in Home-Page.

However, I describe a method, easy to performe, reliable in detecting the presence of oncological terrain, as follows: in healthy, supine and psycho-physically relaxed, during rythmic palpation of breast (similuated sucking test, SST) the mammary gland-gastric aspecific reflex lasts 7 sec. exactly. On the contrary, in oncological terrain the duration augments to 8-9 sec. (p < 0,01) due to prolactin increasing.

In addition, digital pressure, applied 2 cm above external acoustic meatus [=cutaneous projection area of GH-RH  neuronal center], physiologically gastric aspecific reflex, during SS test, continus for < 10 sec., while in case of oncological terrain is ³ 10 sec. in relation to the degree of hormonal dysfunction.

In fact, in such condition there is a loss of balance as far as regards restraining and stimulating substances acting on prolactine secretion (hormons, neuro-transmitters, a.s.o.) in favour of the later ones. Actually, SS test, easy to perform in a few seconds, plays a primary role in detecting complicated modifications in biological systems that defend humans against cancers.

 In healthy, in whom basal value of SST is 7 sec., digital pressure of mean-strong intensity on mandibular nerve lasting 30 sec., induces endogenous opiates secretion, whereas lowers duration of gastric aspecific reflex during SST to £ 6 sec. (NN = 7 sec.). On the contrary, apnea test (10 sec.), by means of sympathetic activation and subsequent adrenaline and nor-adrenaline secretion, brings about the SST to 12 sec.

In presence of oncological terrain, because of hormonal levels and neurotransmettitors modifications, gastric aspecific reflex during to SST,  lasts for more than 12 sec., due to severe reduction of endogenous opiates as well as somatostatine, whereas prolactin clearly increases. Consequently, Biophysical Semeiotics permits doctor to corroborate at the bed-side the relation between immunological process and psycho-neuro-endocrinological, I illustrated clinically in earlier articles (See: Bibliography in Home-Page).

There are other, numerous methods, both rapid and easy to perform at the bed-side, to estimate in reliable manner the presence and intensity of oncological terrain, apart from the “direct” evaluation of GH-RH, ACTH-RH, SST-RH and melatonin-secretion  or to “quantitative” assessment of endogenous opiates, resulting an easy diagnosis, useful for large scale screening.

In following, I describe briefly some very practical method for evaluating oncological terrain:

1)  First doctor evaluates the dimension of cutaneous projection area of one BALT site, than he invites patient  to close intensively both eyes, in order to avoid the light. After 5 sec. or more, of course, in healthy individual,  the same cutaneous area  clearly increases, in direct relation to the intensity of melatonin secretion: normally  diameter doubles reaching the value of 6 cm. (NN = 3 cm.), whereas in oncological terrain  augments slightly: £ 1 cm.

2) Analogously, BALT-gastric aspecific-reflex physiologically shows a lt of 6 sec. (chronic antibodies synthesis), but lowers to 3 sec. after closing both eyes (5 sec. therafter) wiht an intensity
greater than that of basal one. On the contrary, in case of oncological terrain lt as well as intensity of the reflex modifie in a small manner, in inverse relation to the seriousness of  disorder.

3) In healthy subject, apnea test, lasting  for about 10 sec., reduces of 1/3 diameter o cutaneous projection area of a BALT site, whereas in patient involved by oncological terrain the lowering reaches only 2/3 or less.


The assessment of oncological terrain by means of  both Simulated Sucking Test (SST) and simultaneous breast preconditioning  offers to doctors interesting information: one evaluates basal duration of SST , i.e. during rhytmic palpation of a mammalian gland  doctor estimates duration of breast-gastric aspecific reflex, (NN == 7 sec. exactly). After precisely 5 sec., doctor performes again the manoeuvre for a second ( or a third, as he likes it) time.

In healthy subject,  the duration  decreases by degrees to 6 sec and 5 sec, respectively, since dopaminergic tone  of diencephalohypophysial axis physiologically increases. On the contrary, in oncological terrain the duration rises, first to 8 sec. and finally to  ³ 12 sec.

Notoriously, in both this condition and malignant tumours the dopaminergic tone of diencephalohypophysial axis appears reduced and consequently prolactin secretion augments. Therefore, the diagnostic value  of SST and preconditioning is of paramount importance in both ascertaining oncological terrain and diagnosing malignancy.

As a matter of facts, in malignant cancers, solid as well as  liquid, basal SST persists for ³10 sec.; identical value is observed in initial stages of cancer, in patients who successfully underwent  surgery   and, finally, in individual at real risk of tumour, i.e.with oncological terrain.

Before 65 years old  SST is neither age- nor  sex-dipendent (NN = 7 sed. exactly). After apnea test lasting about 10 sec. (= patient does not take any breath)  SST increases from 12 to 20 sec. pathologically (NN = 10 sec. precisely) in onological terrain, so that basal  SST  of 12 sec. in individual under 65 years of age indicates by self  a pathological condition of activated immunological system.  It is of interest that the from CAEMH (=Congenital Acidosic Enzymo-Metabolic Histangiopathy) to Restano’s manoeuvre typ A and, then, type B, of variable intensity, indicating the presence of oncological terrain, the passage is both slow and gradual.

A long, well established experience allows me to state that normocaloric, correct diet and physiological   life-style, as indicated in  the decalogue oa European Society for Study and preventio of Cancer and, finally, the use of histangioprotective drugs (Co Q10, Carnetine, Vit A and E, Bioflavonoidds, Capsaicin, a.s.o.) causes disappearing oncological terrain.

From the practical point of view it is unncessary to search for malignancy when a patient is not ivolved by oncological terrain, i.e. when biophysical semeiotic signs, characteristic of this alteration, e.g. Restano’s manoeuvre type B, are absent. Interestingly, this knowledge is useful for patient, doctor and NHS. On the contrary, in presence of modifications of psycho-neuro-endocrine-immunonogical system, docto must exclude the tumour, even in early stage. Soon thereafter, both efficacious therapy and correct diet  , ethimologically speaking, in order to bring about the normalisation of all altered  parameters, relating to SST, GH, IGfs, endogenous opiates, free Radicals, antioxidants, Co Q10, hyperinsulinemia-insulinresistanceand melatonin.


For the first time doctor can evaluate clinically by means of Biophysical Semeiotics the epiphysial secretion of melatonib, N-acetyl-5-methoxy-triptamin, which notoriously stimulates the antibodies synthesis activating opiates receptors, i.e. indirectly, as well as inhibits both normal and neoplatic cells growing.

Fig. 2

Numerous biophysical semeiotic methods allow doctor to assess melatonin level at the bed-side in easy and reliable manner:

1) in healthy, whose eyes are closed since 5 sec. or mor, antibodies synthesis appears clearly enhanced: for instance,  BALT cutaneous projection area shows its diameters doubled and simultaneously peristaltic waves velocity, e.g. in the stomach, results clearly slower, because it needs ³ 12 sec. for reaching  antral-pyloric region, starting from initial part of the fundus [= ascertained cutaneous projection of the great gastric curvature, doctor gives a pinch to the skin covering breast-bone ensiform appendix: immediately a peristaltic wave originates, which physiologically reaches antral –pyloric region in 5 sec. exactly] . These modifications last for 30 sec. precisely, i.e. their duration results identical to that of melatonin secretion under the same condition (eyes closed) (See later on);

2)  mean-intense digital pressure, applied on epiphysial cutaneous projection area, i.e. 2 cm above and 2 cm posteriorly external acoustic meatus (Fig. 2), after about 5 sec. provokes both the same biophysical semeiotic signs, above described at point 1), which show identical duration, proving clearly internal as well as external coherence of the theory;

3) physiologically intense digital pressure, applied on mandibular branch of nervus trigeminus (trigeminal nerve), starting from ³ 15 sec. brings about endogenous opiates increasing, epiphysial microcirculatory activation type I, associated [= during small digital pressure on epiphisyal neuronal center (Fig.2) ureteral reflexes fluctuate in an intense manner(HS) with fixed periods of 10 sec.], enhancement of antibodie synthesis (“acute type: lt BALT-gastric aspecific reflex 3 sec.) and simoultaneously peristaltic wave slows down:  the time necessary to a wave, originated in initial segment of fundus, for reaching antral-pyloric region,  from 5 sec.rises to  ³ 12 sec.

In oncological terrain melatonin secretion results evidently altered of variable degree from individual to individual, of course, easy to ascertain by the aid of above-illustrated parameters.

Interestingly, a clinical evidence suggests that epiphysial activity  is evaluated in a rapid and reliable manner by means of Biophysical Semeiotics: physiologically stimulating endogenous opiates secretion, with the aid of intense digital pressure on mandibular nerve, the peristaltic wave in the stomach slows down so far that it needs  ³ 12 sec. (NN = 5 sec precisely) for reaching antral-pyloric region. At the same time, intensity of cerebral-gastric aspecific reflex during the evaluation of cerebral evoked potentials [= patient, in supine position and relaxed, push two finger-pulps against each other while doctor estimates lt of cerebral gastric aspecific reflex on right and then, on links hemisphere: in health, lt is 6 sec. and 7 sec. respectively with intensity of 2,5 cm.] decreases from normal value of 2,5 cm. to < 2 cm. If these parameters, however, are evaluated both after the healthy individual closes eyes and the application of intense digital pressure on epiphysial cutaneous projection area for 30 sec. (Fig.2), doctor observes clear modifications of parameters value: lt ³ 10 sec. and < 1,5 cm respectively.

This experimental evidence suggests that melatonin, secreted under this condition, acts directly as well as indirectly by means of endogenous opiates, of which action, therefore, results more efficacious, allowing thus a “quantitative” assessment   of actual level of N-acethyl-5-methoxy-tryptamin.

In addition, clinical evidence demonstrates that melatonin, when associated whith endogenous opiates, stimulates more intensively  acute antibodie synthesis.

In conclusion, in order to ascertain in daily practice oncological terrain, in complete, qualitative as well as quantitative manner, it appears advisable diagnostic iter, easy and reliable, described as follows:

1) evaluation of basal peristaltic wave velocity (NN = 5 sec.);

2) evaluation of GH secretion by mean of the stimulation of its cutaneous prjection area, i.e. GH-RH neuronal centre skin projection (Fig.2), localized 2 cm above external acoustic meatus: in healthy, duration of splenic congestion (enlargment of spleen) is 6 sec., whereas spenic decongestion lasts 20 sec. precisely. Moreover, during this manoeuvre doctor estimates also the time necessary to peristatic gastric wave (even when it is caused by clenching  the skin of Hiss angle cutaneous projection area) to reach antral-pyloric region moving along gastric great curve: ³ 12 sec. (NN = 5 sec.), because GH stimulates somatostatin secretion, that slow down gastro-intestinal peristalsis and bring about splanchnic territoy decongestion.

Staring from 20-25 sec of GH-RH stimulation, evaluated above mentioned parameters, stopped the manoeuvre, immediately doctor estimates SST duration, whis physiologically is < 10  ssec., due to the fact that valid secretion of somatostatin as well as physiological level of dopamine in diencephalohypophysial axis restrain the prolactin secretion, induced by GH. In fact, both substances influence negatively prolactin secretion.

At the  end of the stimulation of GH-RH secretion ( and of all other RHs secretions, of course) in healthy individual pancreas augments its  diameters (practically, pancreatic inferior border lowers due to congestion for exactly 8 sec. Interstingly, this value is fundamental in diagnosing alterations of glucose metabolism. In fact, in case of diabetes mellitus the lowering duration of inferior pancreatic margin amounts to < 8 sec., in direct relation to severity of the syndrome. On the contrary, in both IGT  and hyperinsulinemia-insulinresistance the pancreatic enlargement lasts for > 8 sec. , once again in correlation with the increasing of hormonal secretion, showing  the possibility of evaluating simultaneously different disorders by means of Biophysical Semeiotics , since the numerous biological systems are connetted very closely from both structural and functional point of view.

At this point, oncological terrain is recognized and can be “quantitatively” evaluated  in other manners, as follows:

3) assessment of endogenous opiates, the so-called “immunological orchestra directors” ;

4) estimation of melatonin level, as described above.


As far as the evaluation of endogenous opiates system concerns, that can be activated also by melatonin and myelopeptides, a refined method is represented by assessment of cerebral-gastric aspecific reflex intensity, first, at basal line (NN ³ 2 < 3 cm.)  and, then, after intense digital pressure  on mandibular nerve for 25 sec. , during Cerebral Evoked Potentials (See earlier): in healthy, intensity of cerebral gastric aspecific reflex is reduced to a half., due to the restraining  action of endogeous opiates as regards the neurotransmission.

In oncological terrain, typical lack of  b-endorphins as well as met-enkephalin provokes a very small decreasing of cerebral-gastric aspecific reflex under described condition.

In conclusion, one method, easy and rapid to perform, reliable in both diagnosing and “quantitatively” evaluating oncological terrain, in my opinion, is the following: closed eyes enhance  melatonin epiphysial secretion, constantly reduced in oncological terrain, although whith different degree. Notoriously, melatonin stimulates diencephalohypophysial secretion of SST-RH as well as of  endogenous opiates, particularly in arcuate nucleus. In addition, melatonin, somatostatin, and particularly endogenous opiates stimulate antibodies synthesis. Consequently, BALT cutaneous projection area, evaluated  at rest  and after 5 sec. eyes closure ( patient closes intensively his eyes) appears clearly modified and doubled in healthy for ³ 20 sec., whereas in oncological terrain, in relation to its intensity, changes are minimal  (£ 1 cm.) for only £ 10 sec.

For further information, reader can see Bibliography in this site.

Last update: March 18, 2018